Dr. Sirwan Sleman
University of Sulaimani
Title: Virus-Induced FOXO Protein Facilitates Viral Replication of Human Cytomegalovirus
Biography
Biography: Dr. Sirwan Sleman
Abstract
Forkhead box O (FoxO) plays a critical role in many biological processes and metabolic diseases. Previous studies have demonstrated that FoxOs participate in the pathogenesis of some viral infections including herpesviruses. In our report, we found that human cytomegalovirus (HCMV), a beta herpesvirus member, drastically induced the expression of FoxOs in human fibroblasts. The induced FOXOs were translocated and aggregated into the viral replication compartments (vRC) in the nucleus of the infected cell at the late time post-infection. Besides, the FOXO depletion or exogenous expression remarkably affected viral late gene expression and viral replication but the effect on the viral DNA synthesis was limited to some extent. Our report highlights the new insights into the impact of the FoxO factor on HCMV infection.
Keywords- FoxO and Human Cytomegalovirus, FoxO transcription Factor, HCMV Late Viral Gene Expression, HCMV Infection